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首頁 > 產(chǎn)品中心 > 培養(yǎng)基 > 小分子工具 > StemRD_IWP-2 O-酰基轉(zhuǎn)移酶*抑制劑 10mg WNT家族

_IWP-2 O-酰基轉(zhuǎn)移酶*抑制劑 10mg WNT家族

簡要描述:英文名稱: IWP-2
產(chǎn)品應(yīng)用: WNT通路信號調(diào)控
中國俗稱: IWP-2 抑制劑
注冊品牌: StemRD
生產(chǎn)廠家: 美國StemRD公司
訂購貨號: IWP-10
規(guī)格型號: 10mg
保存溫度: ﹣20℃
產(chǎn)品種類: 小分子工具
到貨時間: 1~5天

  • 產(chǎn)品型號:StemRD
  • 廠商性質(zhì):代理商
  • 更新時間:2021-11-23
  • 訪  問  量:1198
詳細(xì)介紹

產(chǎn)品英文名稱: IWP-2
產(chǎn)品中文名稱: IWP-2


IWP-2 產(chǎn)品英文簡述:
IWP-2:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM (Ref.). Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.


Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 (2009)
 

Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.


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